Cherisa is first seen in the very first scene of the game, reading a book while half-listening to Suki as the latter worries over her impending coronation and her suitability for being Queen. She reassures Suki before she leaves for the night, telling Suki that "tomorrow, [her] life changes forever."
Cherisa accompanies Suki on her journey to the coronation, using a common carriage on a side road. She tells Suki that because the kingdom has received information on a kidnapping attempt by local criminals, the royal carriage has been sent as a decoy on the main road. However, Suki's carriage is stopped by kidnappers; when Suki exits the carriage and confronts the kidnappers, she realizes that the kidnapping is being performed on behalf of Cherisa herself. Cherisa attacks Suki from behind while apologising, chloroforming her.
For a major part of the story, Cherisa is an unseen character; her exploits are reported by other characters. Suki learns from the Guildmaster that, predictably, Cherisa became Queen due to Suki's disappearance. After an excursion on behalf of the guild to Velis Manor, Suki discovers from a captured maid that Cherisa is considered by the people to be a "kind and just ruler" with a reformist mindset, and she remarks internally that she always knew Cherisa would be a better queen than her. She also learns that Cherisa is massing troops for an unknown reason.
Cherisa is next referred to by the Guildmaster before the Ghiaccio Village mission. He informs Suki that Cherisa's troops are blockading Ghiaccio, and this is causing problems for the guild's profits and ability to transport captives. Clearing the blockade, Suki learns from the traitor Lieutenant Riele that Cherisa is being kept in the dark about the situation in Ghiaccio, and her mother apparently has some significant influence over the affairs of the kingdom, such that she can thwart Cherisa's plans.
Travelling to Florian, the party is sidetracked by native warriors in the Jormunga Jungle. The natives have been agitated by the presence of settlers, who intend to mine the jungle, apparently by Cherisa's will, to acquire materials for weapons.
Arriving in Florian, Suki spots the Royal Guard and realises that Cherisa is present there. Eavesdropping on them, she learns that Cherisa is there on a diplomatic mission to avert a war between the Kingdom and a nearby Empire. She and her group infiltrate the castle and make their way to the royal guest chambers, where Suki confronts Cherisa over her kidnapping. Cherisa, surprised to see Suki, explains the truth; she is Queen in name only, and her mother is the true power in the kingdom. Cherisa is kept in line through physical punishment meted out by her mother's servant, Rolina. Cherisa arranged for Suki's kidnapping to save her from a worse fate, as her mother intended to have Suki killed so that Cherisa would ascend to the throne. The conversation is interrupted, and Suki escapes, leaving Cherisa to deal with the consequences of holding a conversation with Suki out of Rolina's earshot.
Cherisa's penultimate appearance comes in the fortress in the Dark Hills, after a second battle with Rolina. Suki enters her chambers to find no one apparently there, but knocking is heard from a dresser, and she opens it to find that Rolina had made good on her promise; Cherisa is locked inside, bound and gagged. Suki swiftly unties her, and she directs them to her mother while imploring Suki not to kill her. Suki agrees.
With her mother defeated, Cherisa reclaims the throne. She withdraws her army from the Dark Hills and reconciles with the Empire.
Suki and Cherisa meet for the last time in-story in the epilogue. Suki decides that it is better for her to remain officially dead, realizing that Cherisa is a better fit for the position of Queen, and that her reappearance may cause political problems. She decides to leave the kingdom and begin her journey of atonement, to Cherisa's sadness, though she pledges to return once she is satisfied she has compensated for the misdeeds she perpetrated as a member of the guild. Cherisa accepts this, and the two part ways.
Cherisa is perhaps the most straight-laced character in the game. Her motives are questionable in the beginning, but she is later revealed to be acting in the best interests of Suki within the constraints of her situation.
She is demonstrated to be studious, wise, educated and refined in manner, and, similarly to Suki, she is apologetic and guilty over what she has had to do, despite having been compelled to act in that way. In contrast with Suki and with many other major characters, she is in no way a fighter, and is never seen in combat.
As Queen, she is shown to hold noble and just intentions, aspiring to reform the Kingdom that she knows is corrupt. Her commitment to this is noted by Suki, who often comments that Cherisa is a better candidate for Queen than she would have been.
She is shown to become very distressed by being tied up, which is abused along with her fear of the dark by Rolina, as a means of controlling her.